KiuClavis
Precision Oncology Intelligence & Evidence Engine
A dual-graph cognitive intelligence portal synthesizing regulatory-grade FDA label truth (Kiu Lens) with preclinical mechanistic convergence (Clavis Lens).
Explore Across Dual Partitioned Lenses
Clinical claims require regulatory-grade validation; preclinical hypotheses require mechanistic exploration. KiuClavis partitions both into dedicated cryptographic graph tiers.
The Kiu Lens
Anchored strictly in FDA drug labels, regulatory clearances, companion diagnostic requirements, and algebraic RECIST 1.1 audited response data.
The Clavis Lens
Explores signaling pathway convergence, secondary resistance mechanisms, synthetic lethal partners, and emerging preclinical target vulnerabilities.
Core Platform Capabilities & Research Portals
Interactive tools, structural biology viewers, and curated oncology monographs.
The Switch That Took Forty Years to Flip
Precision Oncology · Covalent Chemistry · Sotorasib vs. Adagrasib Head-to-Head
From picomolar GTP affinity to Kevan Shokat's cryptic switch-II pocket discovery. Explore atomic crystal coordinates (PDB: 6OIM & 6V9F), covalent Michael addition mechanisms, and RECIST-validated clinical trial comparisons (CodeBreaK 100 vs. KRYSTAL-1).
Interactive Pathway Map
Visualize signal transduction through the MAPK/ERK, PI3K/AKT, and RTK axes with live drug nodes, resistance bypass routes, and phosphorylation states.
Multi-Agent Query Engine
Multi-agent consensus synthesis powered by epistemic scoring, provenance lineage tracking, and deterministic ontology resolution.
Blood Atlas & Liquid Biopsy
Circulating tumor DNA (ctDNA) dynamics, minimal residual disease (MRD) monitoring, and longitudinal variant allele frequency tracking.
The Five-Gate Pipeline & RECIST Mathematical Constraints
Ingress Sanitization
Strips unhedged clinical recommendations and validates structure.
RECIST 1.1 Invariant Audit
Enforces count conservation, ORR/DCR monotonicity, and patient totals.
Preflight Graph Guard
Strict partition between Canonical Graph and exploratory Shadow Graph.
Span Provenance
Cryptographic SHA-256 hashing bound to authoritative registry locators.
CAS Drift Detection
Write verification and immutable read-back check preventing database drift.